diff --git a/compiler/rustc_monomorphize/src/collector.rs b/compiler/rustc_monomorphize/src/collector.rs
index 173030e0326e..e90e32ebebb9 100644
--- a/compiler/rustc_monomorphize/src/collector.rs
+++ b/compiler/rustc_monomorphize/src/collector.rs
@@ -949,6 +949,9 @@ fn visit_instance_use<'tcx>(
         }
         ty::InstanceKind::DropGlue(_, None) => {
             // Don't need to emit noop drop glue if we are calling directly.
+            //
+            // Note that we also optimize away the call to visit_instance_use in vtable construction
+            // (see create_mono_items_for_vtable_methods).
             if !is_direct_call {
                 output.push(create_fn_mono_item(tcx, instance, source));
             }
@@ -1177,8 +1180,13 @@ fn create_mono_items_for_vtable_methods<'tcx>(
         output.extend(methods);
     }
 
-    // Also add the destructor.
-    visit_drop_use(tcx, impl_ty, false, source, output);
+    // Also add the destructor, if it's necessary.
+    //
+    // This matches the check in vtable_allocation_provider in middle/ty/vtable.rs,
+    // if we don't need drop we're not adding an actual pointer to the vtable.
+    if impl_ty.needs_drop(tcx, ty::TypingEnv::fully_monomorphized()) {
+        visit_drop_use(tcx, impl_ty, false, source, output);
+    }
 }
 
 /// Scans the CTFE alloc in order to find function pointers and statics that must be monomorphized.
diff --git a/tests/codegen-units/item-collection/drop-glue-noop.rs b/tests/codegen-units/item-collection/drop-glue-noop.rs
new file mode 100644
index 000000000000..604ba883bb28
--- /dev/null
+++ b/tests/codegen-units/item-collection/drop-glue-noop.rs
@@ -0,0 +1,23 @@
+//@ compile-flags:-Clink-dead-code -Zmir-opt-level=0
+
+#![deny(dead_code)]
+#![crate_type = "lib"]
+
+//~ MONO_ITEM fn start
+#[no_mangle]
+pub fn start(_: isize, _: *const *const u8) -> isize {
+    // No item produced for this, it's a no-op drop and so is removed.
+    unsafe {
+        std::ptr::drop_in_place::<u32>(&mut 0);
+    }
+
+    // No choice but to codegen for indirect drop as a function pointer, since we have to produce a
+    // function with the right signature. In vtables we can avoid that (tested in
+    // instantiation-through-vtable.rs) because we special case null pointer for drop glue since
+    // #122662.
+    //
+    //~ MONO_ITEM fn std::ptr::drop_in_place::<u64> - shim(None) @@ drop_glue_noop-cgu.0[External]
+    std::ptr::drop_in_place::<u64> as unsafe fn(*mut u64);
+
+    0
+}