diff --git a/src/tools/compiletest/src/header.rs b/src/tools/compiletest/src/header.rs
index cc972223f6df..65436a8a4401 100644
--- a/src/tools/compiletest/src/header.rs
+++ b/src/tools/compiletest/src/header.rs
@@ -1023,9 +1023,6 @@ fn iter_header(
     if mode == Mode::CoverageRun {
         let extra_directives: &[&str] = &[
             "needs-profiler-support",
-            // FIXME(mati865): MinGW GCC miscompiles compiler-rt profiling library but with Clang it works
-            // properly. Since we only have GCC on the CI ignore the test for now.
-            "ignore-windows-gnu",
             // FIXME(pietroalbini): this test currently does not work on cross-compiled
             // targets because remote-test is not capable of sending back the *.profraw
             // files generated by the LLVM instrumentation.
diff --git a/tests/run-make/optimization-remarks-dir-pgo/Makefile b/tests/run-make/optimization-remarks-dir-pgo/Makefile
index 3bc3d7d14288..57ffd6e70f00 100644
--- a/tests/run-make/optimization-remarks-dir-pgo/Makefile
+++ b/tests/run-make/optimization-remarks-dir-pgo/Makefile
@@ -1,10 +1,6 @@
 # needs-profiler-support
-# ignore-windows-gnu
 # ignore-cross-compile
 
-# FIXME(mati865): MinGW GCC miscompiles compiler-rt profiling library but with Clang it works
-# properly. Since we only have GCC on the CI ignore the test for now.
-
 include ../tools.mk
 
 PROFILE_DIR=$(TMPDIR)/profiles
diff --git a/tests/run-make/pgo-branch-weights/rmake.rs b/tests/run-make/pgo-branch-weights/rmake.rs
index 55f6e7e56c5a..d3cb79c39afa 100644
--- a/tests/run-make/pgo-branch-weights/rmake.rs
+++ b/tests/run-make/pgo-branch-weights/rmake.rs
@@ -10,10 +10,6 @@
 //@ needs-profiler-support
 //@ ignore-cross-compile
 
-// FIXME(Oneirical): This test has problems generating profdata on mingw.
-// For more information, see https://github.com/rust-lang/rust/pull/122613
-//@ ignore-windows-gnu
-
 use run_make_support::{fs_wrapper, llvm_filecheck, llvm_profdata, run_with_args, rustc};
 use std::path::Path;
 
diff --git a/tests/run-make/pgo-gen-lto/Makefile b/tests/run-make/pgo-gen-lto/Makefile
index 8b647846af3b..54164c995222 100644
--- a/tests/run-make/pgo-gen-lto/Makefile
+++ b/tests/run-make/pgo-gen-lto/Makefile
@@ -1,10 +1,6 @@
 # needs-profiler-support
-# ignore-windows-gnu
 # ignore-cross-compile
 
-# FIXME(mati865): MinGW GCC miscompiles compiler-rt profiling library but with Clang it works
-# properly. Since we only have GCC on the CI ignore the test for now.
-
 include ../tools.mk
 
 COMPILE_FLAGS=-Copt-level=3 -Clto=fat -Cprofile-generate="$(TMPDIR)"
diff --git a/tests/run-make/pgo-gen/Makefile b/tests/run-make/pgo-gen/Makefile
index bf32cfdb802f..c1d456986fb2 100644
--- a/tests/run-make/pgo-gen/Makefile
+++ b/tests/run-make/pgo-gen/Makefile
@@ -1,10 +1,6 @@
 # needs-profiler-support
-# ignore-windows-gnu
 # ignore-cross-compile
 
-# FIXME(mati865): MinGW GCC miscompiles compiler-rt profiling library but with Clang it works
-# properly. Since we only have GCC on the CI ignore the test for now.
-
 include ../tools.mk
 
 COMPILE_FLAGS=-g -Cprofile-generate="$(TMPDIR)"
diff --git a/tests/run-make/pgo-indirect-call-promotion/Makefile b/tests/run-make/pgo-indirect-call-promotion/Makefile
index 542eb244d395..8d1e69c4aba3 100644
--- a/tests/run-make/pgo-indirect-call-promotion/Makefile
+++ b/tests/run-make/pgo-indirect-call-promotion/Makefile
@@ -1,10 +1,6 @@
 # needs-profiler-support
-# ignore-windows-gnu
 # ignore-cross-compile
 
-# FIXME(mati865): MinGW GCC miscompiles compiler-rt profiling library but with Clang it works
-# properly. Since we only have GCC on the CI ignore the test for now.
-
 include ../tools.mk
 
 all:
diff --git a/tests/run-make/pgo-use/Makefile b/tests/run-make/pgo-use/Makefile
index 9f440118daee..92098a4019c4 100644
--- a/tests/run-make/pgo-use/Makefile
+++ b/tests/run-make/pgo-use/Makefile
@@ -1,10 +1,6 @@
 # needs-profiler-support
-# ignore-windows-gnu
 # ignore-cross-compile
 
-# FIXME(mati865): MinGW GCC miscompiles compiler-rt profiling library but with Clang it works
-# properly. Since we only have GCC on the CI ignore the test for now.
-
 include ../tools.mk
 
 # This test makes sure that PGO profiling data leads to cold functions being
diff --git a/tests/run-make/track-pgo-dep-info/Makefile b/tests/run-make/track-pgo-dep-info/Makefile
index 6c7f67d0f0a9..3afe3662fa75 100644
--- a/tests/run-make/track-pgo-dep-info/Makefile
+++ b/tests/run-make/track-pgo-dep-info/Makefile
@@ -1,5 +1,4 @@
 # needs-profiler-support
-# ignore-windows-gnu
 
 include ../tools.mk