diff --git a/src/tools/rust-analyzer/editors/code/src/ctx.ts b/src/tools/rust-analyzer/editors/code/src/ctx.ts
index ac73f2ae6bf1..37a2ee236915 100644
--- a/src/tools/rust-analyzer/editors/code/src/ctx.ts
+++ b/src/tools/rust-analyzer/editors/code/src/ctx.ts
@@ -5,6 +5,7 @@ import * as ra from "./lsp_ext";
 import { Config, prepareVSCodeConfig } from "./config";
 import { createClient } from "./client";
 import {
+    isCargoTomlEditor,
     isDocumentInWorkspace,
     isRustDocument,
     isRustEditor,
@@ -429,6 +430,11 @@ export class Ctx implements RustAnalyzerExtensionApi {
         return editor && isRustEditor(editor) ? editor : undefined;
     }
 
+    get activeCargoTomlEditor(): RustEditor | undefined {
+        const editor = vscode.window.activeTextEditor;
+        return editor && isCargoTomlEditor(editor) ? editor : undefined;
+    }
+
     get extensionPath(): string {
         return this.extCtx.extensionPath;
     }
diff --git a/src/tools/rust-analyzer/editors/code/src/run.ts b/src/tools/rust-analyzer/editors/code/src/run.ts
index f71ab7ffbd81..40027cc7c857 100644
--- a/src/tools/rust-analyzer/editors/code/src/run.ts
+++ b/src/tools/rust-analyzer/editors/code/src/run.ts
@@ -7,7 +7,7 @@ import type { CtxInit } from "./ctx";
 import { makeDebugConfig } from "./debug";
 import type { Config } from "./config";
 import type { LanguageClient } from "vscode-languageclient/node";
-import { unwrapUndefinable, type RustEditor } from "./util";
+import { log, unwrapUndefinable, type RustEditor } from "./util";
 
 const quickPickButtons = [
     { iconPath: new vscode.ThemeIcon("save"), tooltip: "Save as a launch.json configuration." },
@@ -19,7 +19,7 @@ export async function selectRunnable(
     debuggeeOnly = false,
     showButtons: boolean = true,
 ): Promise<RunnableQuickPick | undefined> {
-    const editor = ctx.activeRustEditor;
+    const editor = ctx.activeRustEditor ?? ctx.activeCargoTomlEditor;
     if (!editor) return;
 
     // show a placeholder while we get the runnables from the server
@@ -175,10 +175,17 @@ async function getRunnables(
         uri: editor.document.uri.toString(),
     };
 
-    const runnables = await client.sendRequest(ra.runnables, {
-        textDocument,
-        position: client.code2ProtocolConverter.asPosition(editor.selection.active),
-    });
+    const runnables = await client
+        .sendRequest(ra.runnables, {
+            textDocument,
+            position: client.code2ProtocolConverter.asPosition(editor.selection.active),
+        })
+        .catch((err) => {
+            // If this command is run for a virtual manifest at the workspace root, then this request
+            // will fail as we do not watch this file.
+            log.error(`${err}`);
+            return [];
+        });
     const items: RunnableQuickPick[] = [];
     if (prevRunnable) {
         items.push(prevRunnable);
diff --git a/src/tools/rust-analyzer/editors/code/src/util.ts b/src/tools/rust-analyzer/editors/code/src/util.ts
index 2f7702baebb6..93c7bf8d73e7 100644
--- a/src/tools/rust-analyzer/editors/code/src/util.ts
+++ b/src/tools/rust-analyzer/editors/code/src/util.ts
@@ -90,6 +90,10 @@ export function isRustEditor(editor: vscode.TextEditor): editor is RustEditor {
     return isRustDocument(editor.document);
 }
 
+export function isCargoTomlEditor(editor: vscode.TextEditor): editor is RustEditor {
+    return isCargoTomlDocument(editor.document);
+}
+
 export function isDocumentInWorkspace(document: RustDocument): boolean {
     const workspaceFolders = vscode.workspace.workspaceFolders;
     if (!workspaceFolders) {