diff --git a/compiler/rustc_borrowck/src/type_check/liveness/mod.rs b/compiler/rustc_borrowck/src/type_check/liveness/mod.rs
index f23602d03588..4e0b2a4e2968 100644
--- a/compiler/rustc_borrowck/src/type_check/liveness/mod.rs
+++ b/compiler/rustc_borrowck/src/type_check/liveness/mod.rs
@@ -38,11 +38,19 @@ pub(super) fn generate<'a, 'tcx>(
 ) {
     debug!("liveness::generate");
 
-    let free_regions = regions_that_outlive_free_regions(
-        typeck.infcx.num_region_vars(),
-        &typeck.universal_regions,
-        &typeck.constraints.outlives_constraints,
-    );
+    // NLLs can avoid computing some liveness data here because its constraints are
+    // location-insensitive, but that doesn't work in polonius: locals whose type contains a region
+    // that outlives a free region are not necessarily live everywhere in a flow-sensitive setting,
+    // unlike NLLs.
+    let free_regions = if !typeck.tcx().sess.opts.unstable_opts.polonius.is_next_enabled() {
+        regions_that_outlive_free_regions(
+            typeck.infcx.num_region_vars(),
+            &typeck.universal_regions,
+            &typeck.constraints.outlives_constraints,
+        )
+    } else {
+        typeck.universal_regions.universal_regions_iter().collect()
+    };
     let (relevant_live_locals, boring_locals) =
         compute_relevant_live_locals(typeck.tcx(), &free_regions, body);