diff --git a/src/librustc/infer/error_reporting/mod.rs b/src/librustc/infer/error_reporting/mod.rs
index c477a0d383e2..3cd7c5e0af3e 100644
--- a/src/librustc/infer/error_reporting/mod.rs
+++ b/src/librustc/infer/error_reporting/mod.rs
@@ -66,7 +66,7 @@ use hir::map as hir_map;
 use hir::def_id::DefId;
 use middle::region;
 use traits::{ObligationCause, ObligationCauseCode};
-use ty::{self, Region, Ty, TyCtxt, TypeFoldable, TypeVariants};
+use ty::{self, Region, RegionKind, Ty, TyCtxt, TypeFoldable, TypeVariants};
 use ty::error::TypeError;
 use syntax::ast::DUMMY_NODE_ID;
 use syntax_pos::{Pos, Span};
@@ -1067,6 +1067,40 @@ impl<'a, 'gcx, 'tcx> InferCtxt<'a, 'gcx, 'tcx> {
                                sub_region: Region<'tcx>,
                                sup_origin: SubregionOrigin<'tcx>,
                                sup_region: Region<'tcx>) {
+
+        // #45983: when trying to assign the contents of an argument to a binding outside of a
+        // closure, provide a specific message pointing this out.
+        if let (&SubregionOrigin::BindingTypeIsNotValidAtDecl(ref external_span),
+                &SubregionOrigin::Subtype(TypeTrace { ref cause, .. }),
+                &RegionKind::ReFree(ref free_region)) = (&sub_origin, &sup_origin, sup_region) {
+            let hir = &self.tcx.hir;
+            if let Some(node_id) = hir.as_local_node_id(free_region.scope) {
+                match hir.get(node_id) {
+                    hir_map::NodeExpr(hir::Expr {
+                        node: hir::ExprClosure(_, _, _, closure_span, false),
+                        ..
+                    }) => {
+                        let sp = var_origin.span();
+                        let mut err = self.tcx.sess.struct_span_err(
+                            sp,
+                            "borrowed data cannot be moved outside of its closure");
+                        let label = match cause.code {
+                            ObligationCauseCode::ExprAssignable => {
+                                "cannot be assigned to binding outside of its closure"
+                            }
+                            _ => "cannot be moved outside of its closure",
+                        };
+                        err.span_label(sp, label);
+                        err.span_label(*closure_span, "closure you can't escape");
+                        err.span_label(*external_span, "binding declared outside of closure");
+                        err.emit();
+                        return;
+                    }
+                    _ => {}
+                }
+            }
+        }
+
         let mut err = self.report_inference_failure(var_origin);
 
         self.tcx.note_and_explain_region(region_scope_tree, &mut err,
diff --git a/src/test/compile-fail/regions-escape-bound-fn-2.rs b/src/test/compile-fail/regions-escape-bound-fn-2.rs
index 1329d05a0f69..042c55eed866 100644
--- a/src/test/compile-fail/regions-escape-bound-fn-2.rs
+++ b/src/test/compile-fail/regions-escape-bound-fn-2.rs
@@ -16,5 +16,5 @@ fn with_int<F>(f: F) where F: FnOnce(&isize) {
 fn main() {
     let mut x = None;
     with_int(|y| x = Some(y));
-         //~^ ERROR cannot infer
+         //~^ ERROR borrowed data cannot be moved outside of its closure
 }
diff --git a/src/test/ui/borrowck/issue-45983.rs b/src/test/ui/borrowck/issue-45983.rs
new file mode 100644
index 000000000000..b2316a6b61c8
--- /dev/null
+++ b/src/test/ui/borrowck/issue-45983.rs
@@ -0,0 +1,19 @@
+// Copyright 2018 The Rust Project Developers. See the COPYRIGHT
+// file at the top-level directory of this distribution and at
+// http://rust-lang.org/COPYRIGHT.
+//
+// Licensed under the Apache License, Version 2.0 <LICENSE-APACHE or
+// http://www.apache.org/licenses/LICENSE-2.0> or the MIT license
+// <LICENSE-MIT or http://opensource.org/licenses/MIT>, at your
+// option. This file may not be copied, modified, or distributed
+// except according to those terms.
+
+fn give_any<F: for<'r> FnOnce(&'r ())>(f: F) {
+    f(&());
+}
+
+fn main() {
+    let x = None;
+    give_any(|y| x = Some(y));
+    //~^ ERROR borrowed data cannot be moved outside of its closure
+}
diff --git a/src/test/ui/borrowck/issue-45983.stderr b/src/test/ui/borrowck/issue-45983.stderr
new file mode 100644
index 000000000000..689fe6053c9a
--- /dev/null
+++ b/src/test/ui/borrowck/issue-45983.stderr
@@ -0,0 +1,12 @@
+error: borrowed data cannot be moved outside of its closure
+  --> $DIR/issue-45983.rs:17:27
+   |
+16 |     let x = None;
+   |         - binding declared outside of closure
+17 |     give_any(|y| x = Some(y));
+   |              ---          ^ cannot be assigned to binding outside of its closure
+   |              |
+   |              closure you can't escape
+
+error: aborting due to previous error
+